Unveil the world of Mutations in Fallout 76, a source of potent buffs with potential drawbacks. Whether obtained early through trade or radiation exposure, Mutations offer substantial enhancements but demand careful consideration due to their negative effects.
By leveraging appropriate perk combinations, players can transform Mutations into permanent enhancements, amplifying benefits and mitigating drawbacks. While stacking Mutations has no limit, it's crucial to evaluate the worthiness of enduring associated downsides.
Top-Tier Mutations
- Adrenal Reaction
- Carnivore
- Empath
- Herbivore
- Herd Mentality
- Speed Demon
These premier Mutations deliver versatile buffs suitable for various playstyles. For example, Adrenal Reaction synergizes with the Bloodied Meta, doubling weapon damage when combined with specific perks and low health. Carnivore and Herbivore cater to melee and critical hit-focused builds respectively, offering specialized benefits.
Specialized Mutations
- Eagle Eyes
- Marsupial
- Scaly Skin
- Talons
- Twisted Muscles
These Mutations are tailored for niche builds, enhancing specific weapon types while potentially penalizing others. Players dedicated to single weapon strategies can maximize these buffs after curing themselves of any adverse effects.
Neutral Mutations
- Chameleon
- Electrically Charged
- Plague Walker
- Unstable Isotopes
Occupying a middle ground, these Mutations offer unique effects without significant drawbacks. They are valuable for expanding Mutation counts to fully utilize Mutant Legendary gear in Fallout 76. However, their impact may vary based on playstyle.
Conditional Mutations
- Bird Bones
- Healing Factor
While these Mutations possess tradeoffs, they can benefit specific builds with the right perk investments. Notably, Bird Bones reduces fall damage, proving redundant for Power Armor users who are immune to such damage.
Lower-Tier Mutations
- Egg Head
- Grounded
With significant drawbacks, these Mutations offer limited benefits even with perk mitigation. They are best suited for temporary use or players capable of curing them promptly.